Cocaine interferes with the brain's signalling processes by blocking the removal of neurotransmitters from synapses. In particular, cocaine binds with transport molecules responsible for the uptake of dopamine, causing dopamine to accumulate within the synapses. Because the presence of dopamine is integral to the brain's reward system, the buildup of dopamine amplifies reward signals, stimulating a feeling of euphoria. Over time, cocaine can lead to abnormalities in the cortex region of the brain, and is associated with impairments to cognition, motor function, and reaction time. Dependency on cocaine can develop from long-term use and depression is common if usage is stopped.
[P1] Cocaine builds up dopamine levels to give feelings of euphoria.